The vampire Emma parks her car on the shoulder of a road and asks for a ride. A man named Carl gives a ride in his pickup and tries to rape her, but Emma kills him and drink his blood. Later she uses the same procedure and a man named Frank gives a ride, but she spares him since he is a family man. While on the road waiting for her next victim, a car stops and the driver is her estranged sister Scarlett, who wants to tell Emma that their missing sister Kate is alive and living with the vampire hunter Bullseye. Further, the powerful vampire Thorn and his right-arm Tatiana are hunting her down since she is a scientist and is researching a vaccine to heal humans from vampirism. Emma meets the handsome Marcus in a bar, and they have one night stand in her hotel room. When Emma comes to the room, she says that she had had a love affair with Marcus. He tells Emma that he likes her and decides to join their quest to find Kate. Meanwhile, Emma and Scarlett recall when their foster parents were killed by vampires, and they turned into vampires being accepted to join Thorn's family.