The movie centers around the Quinns and DeLucas who have lived next door to each other for decades in the shadow of Highmark Stadium - the home of their beloved Buffalo Bills. With their longtime friendship rooted in being proud members of Bills Mafia, the two clans have enjoyed cherished traditions that revolve around cheering for their favorite team - especially at the holidays when they celebrate the last home game before Christmas. Pediatric doctor Morgan Quinn (Roden) and the Bills' VP of Stadium Development Gabe DeLuca (Daddario) have always been close friends, but Gabe has always held a torch for her -a fact obvious to their families (Pollan, Aaron, Schirripa, Murin)...and everyone else who crosses their path. When Morgan learns from her Uncle Tommy (Danza) that someone anonymously helped her family get by after he was drafted more than 60 years ago - and that he continues to receive a Christmas gift each year to this day - she decides to find his benefactor and give her uncle a Christmas he'll always remember. Aided by Bills Mafia friends of theirs, Morgan and Gabe work together to unwrap the gifter's identity. Along the way, Gabe's love for Morgan deepens and in turn, she begins to see him in a new light though neither is daring enough to admit their feelings. Meanwhile, Morgan's hopes of pulling off her surprise for Uncle Tommy get sacked. That is, until Gabe takes matters into his own hands and uses his connections with the Bills to pull off the surprise of a lifetime for Morgan and both their families that will make this a Christmas they'll never forget.