In Clinton, Mississippi, Detective Lucas Boyd is tasked with investigating a string of gruesome murders that appear to be connected to an African ritual known as Muti. Boyd is initially confounded by the nature of the murders and the seemingly ritualistic manner in which they are carried out. As he delves deeper into the case, he realizes that he needs the help of someone with expertise in African culture and customs. Boyd reaches out to Dr. Mackles, an African scholar, for assistance in deciphering the ritualistic elements of the murders. Together, they explore the cultural significance of Muti and its possible connection to the crimes in Clinton. As they work to unravel the mystery, they face resistance from local authorities who are skeptical of their unconventional approach to the case. Boyd and Dr. Mackles must navigate the complexities of cultural differences and overcome their own personal biases to solve the case.