A tale of friendship, trust, betrayal and the overwhelming power of unconditional love. The story follows a gang of unique outcasts and misfits living in a downtown Los Angeles fleapit, known locally as the "Million Dollar Hotel." Their story is seen through the eyes of Tom Tom (Jeremy Davies), a young man who serves them all like some sort of "Beggar's Butler." He has a childlike, innocent mind. Tom Tom has fallen head over heels for the tarnished street angel Eloise (Milla Jovovich). As their relationship develops, the Million Dollar Hotel becomes the focus of a police investigation: one of the residents, the engaging junkie Izzy (Tim Roth), has come to a grisly end --- having fallen off the roof. Or was he pushed? To the amazement of his neighbors, Izzy is revealed to have been the son of a billionaire media magnate Harris Yulin (Harris Yulin). Every inhabitant of the Million Dollar Hotel falls under suspicion in the inquiry led by FBI hard-liner, Detective Skinner (Mel Gibson). As Skinner's investigation proceeds, the lines between murder and suicide become very blurred, indeed.