Like the original movie 25 years ago, a teenage girl is at home alone when the phone rings. A man wants to play a game with her. With the threat of killing her best friend, Tara's forced to play along. She barely survives the ghost face masked intruder's stabbing. Her 5 year older sister, Sam(antha), who left home at 18 due to mental problems, Sam's boyfriend and Tara's high school friends visit her at the hospital. Later on in a bar, a guy provokes the friends and is later attacked outside in the parking lot by Ghostface. Sam receives a call from him at the hospital and then he unsuccessfully attacks her. She later reveals family secrets to her sister. Sam contacts one of the original victims, Dewey, for help. He warns two other original victims, Sidney Prescott and Gale Weathers, about Ghostface being back. Who is Ghostface? How many more must die?