Twelve people are aboard Coast Air Line's flagship the Silver Queen enroute to South America when the airplane encounters a storm and is blown off course. Crashing into jungles known to be inhabited by head hunters, pilots Bill and Joe race against time to fix the engines and attempt a take off. The situation brings out the best and worst in the stranded dozen as they create a makeshift runway and prepare to escape before the natives attack. But damage to the plane and low fuel reserves means that only 5 people can be carried to safety. Do both Bill and Joe make the flight out? And what about the rest: Peggy, a woman with a slightly tarnished past; Pete, a racketeer who is escorting his boss's young son Tommy; Alice and Judson, eloping lovers who seem to have less in common as their plight changes one of them in the other's eyes; Crimp, who is bringing criminal Vasquez to justice; Prof. and Mrs. Spengler, an elderly couple whom become closer due to their predicament; and finally, is flight attendant Larry among the five? And who decides who lives and dies?